The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse

Article Abstract:

ActRIB, a type I transmembrane serine-threonine kinase receptor, is necessary for gastrulation and egg cylinder organization in mice and seems to mediate signals necessary for those developments. ActRIB-deficient ES cell lines and mice were generated by targeting of genes. The epiblast and the extraembryonic ectoderm were disorganized in the ActRIB-/- embryos that resulted. The result was disruption and arresting of the development of the egg cylinder before gastrulation. Chimera analysis was carried out to find the function of ActRIB in mesoderm formation and gastrulation.

Methods, Abnormalities, Genetic aspects, Genetic regulation, Gene expression, Genetic transcription, Transcription (Genetics), Molecular biology, Cell membranes, Mesoderm, Gastrulation

---

Disruption of alpha 3 connexin gene leads to proteolysis and cataractogenesis in mice

Article Abstract:

Mutation of the alpha3 connexin gene in mice did not affect the initial formation of lenses and lens fiber differentiation but caused proteolytic degradation of crystallins in mice with a double dose of the mutant gene. This led to the development of nuclear cataracts. These results reveal the importance of gap junctions in the maintenance of lens transparency. Gap junctions are the means of adjacent cell to communicate with one another and may function as a structural component in cellular organization.

Causes of, Physiological aspects, Cataract, Cataracts, Crystalline lens

---

The gap junction communication channel

Article Abstract:

Cell communication is essential to maintain the organization of cells. It coordinates cellular activities while at the same time, lets cells retain their individuality. Direct cell-cell contact is achieved via specialized cell surface membrane structures called gap junctions. Gap junctions are made up of a family of proteins called connexins which define the properties of gap junction channels such as permeability to molecules and voltage sensitivity.

Cell interaction, Cell interactions

Similar abstracts:

• Abstracts: Oocyte-specific expression of Gpr3 is required for the maintenance of meiotic arrest in mouse oocytes
• Abstracts: The small ubiquitin-like modifier (SUMO) is required for gonadal and uterine-vulval morphogenesis in Caenorhabditis elegans
• Abstracts: Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo. Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters
• Abstracts: The CLAVATA1 gene encodes a putative receptor kinase that controls shoot and floral meristem size in Arabidopsis
• Abstracts: Use of the KlADH4 promoter for ethanol-dependent production of recombinant human serum albumin in Kluyveromyces lactis

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.