The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing
Article Abstract:
The prototypical yeast transcription factor Gal4 undergoes two distinct modes of ubiquitin-mediated proteolysis, one that occurs independent of transcription and restricts Gal4 function, and another that is transcription coupled and essential for productive activation of Gal4 target genes. Gal4 ubiquitylation and destruction are required for initiation-competent transcription complexes to transition to fully mature elongating complexes capable of appropriate mRNA processing.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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A palmitoylation switch mechanism in the regulation of the visual cycle
Article Abstract:
The new roles for palmitoylated proteins as molecular switches and lecithin retinol acyl transferase (LRAT) as a palmitoyl transferase whose role is to catalyze the mPRE65 to sRPE65 are presented. It is shown that mRPE65 is a palmitoyl donor, revealing a new acyl carrier protein role for palmitoylated proteins.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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MicroRNAs: genomics, biogenesis, mechanism, and function
Article Abstract:
The regulatory role played by microRNAs (mRNAs) in animals and plants by targeting mRNAs for cleavage translational repression is discussed. The probable influence of mRNA on the output of many protein-coding genes is highlighted.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
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