The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
Article Abstract:
Sterol regulatory element binding proteins (SREBP) control transcription of cholesterol synthesis by regulating the transcription of 3-hydroxy-3-methyl- glutaryl coenzyme A (HMGCoA) reductase, an enzyme responsible for controllinglevels of cholesterol in the body, regulates LDL receptor which supplies cholesterol through receptor-mediated endocytosis, and also adjusts transcription of genes encoding enzymes of fatty acid synthesis and uptake. To accomplish transcription, SREBPs should be cleaved from the membrane to enter the nucleus and this process is facilitated by mutant SREBP cleavage activation protein (SCAP).
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein
Article Abstract:
cDNA cloning of component A of Rab geranylgeranyl transferase, analogous to Rab 3A guanine nucleotide dissociation inhibitor (GD1), forms a complex with Rab 1A. The complex exposes the nascent enzyme, and detaches the prenylated Rab protein from the catalytic subunits following the transfer reaction, thereby reexposing the catalytic site. Component A plays the role of an escort for the Rab proteins during and after the prenyl transfer reaction, and is known as Rab Escort Protein (REP).
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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Protein sensors for membrane sterols
Article Abstract:
Recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake are discussed. Cholesterol is an essential component of animal cell membranes, and its concentration is tightly controlled by a feedback system that operates the transcription and posttranscriptional levels.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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