Phage T4 homologous strand exchange: a DNA helicase, not the strand transferase, drives polar branch migration
Article Abstract:
Reconstruction of a multiprotein complex made of five bacteriophage T4 proteins shows that strand transferases are necessary for homologous DNA pairing in vivo and branch migration is mediated by DNA helicase. The UvsY protein is required for homologous pairing but it inhibits branch migration mediated by the UvsX protein. Polar branch migration is dependent DNA helicase and an accessory protein.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Keeping transcriptional activators under control
Article Abstract:
The available data suggests that rapid and slower mechanisms that modulate the stability of promoter-bound transcription complexes exist. Some of these mechanisms involve the proteasome, others do not but different activators employ these mechanisms to different extents leading a wide spectrum of dynamic behaviors of activator-promoter complexes within cells.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
User Contributions:
Comment about this article or add new information about this topic: