The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin
Article Abstract:
Receptor-type protein tyrosine phosphatase beta (RPTP beta) is manifested in the growing nervous system and carries a carbonic anhydrase (CAH) domain and a fibronectin type III repeat in its extracellular domain. Fusion proteins carrying these domains were employed to look for ligands of RPTP beta. The CAH domain bound particularly to a 140 kDa protein manifested on the surface of neuronal cells. Expression cloning in COS7 cells showed that this protein is contactin, a GPI membrane-anchored neuronal cell identification molecule.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Direct binding and activation of receptor tyrosine kinases by collagen
Article Abstract:
Receptor tyrosine kinases are important in cell growth control, differentiation, metabolism and cell migration. A general method for ligand-induced activation of receptor tyrosine kinases has been developed, whereby ligand binding to the extracellular domain induces receptor dimerization. There is convincing evidence for activation of DDR receptors by collagen fibers.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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New roles for Src kinases in control of cell survival and angiogenesis
Article Abstract:
This article examines the important role played by Src kinases in lymphokine-mediated cell survival and VEGF-induced angiogenesis. The data point out that Src kinases control cell survival by inhibiting cell apoptosis which in turn is regulated by VEGF.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
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