Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo
Article Abstract:
Accurate expression of some genes in yeast depends on the transcriptional coactivator Gcn5p. Several transcriptional regulators, Gcn5p among them, have intrinsic histone acetyltransferase (HAT) activity in vitro. Whether HAT activity of any of the proteins is necessary for gene activation has not been certain. HAT activity of Gcn5p has been found to be essential for transcription activation of target genes in vivo. In vivo data indicate that promoter-specific histone acetylation catalyzed by functional Gcn5p has an essential role in gene activation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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Telomere-mediated plasmid segregation in Saccharomyces cerevisiae involves gene products required for transcriptional repression at silencers and telomeres
Article Abstract:
The TG telomere repeat sequences of Saccharomyces cerevisiae confers efficient segregation of plasmidscontaining the sequence (TRS plasmids) during mitosis. However, H4 histone mutation abolishes this efficiency indicating that the chromatin structure is involved in the segregation process. Although, Sir1, Sir2, Sir3 and Sir4 are necessary for transcription of the genes in the sequence, and to some extent, the segregation of the TRS plasmids, mutation in these genes do not completely abolish segregation efficiency.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1993
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Chromatin assembly factor I contributes to the maintenance , but not the re-establishment, of silencing at the yeast silent mating loci
Article Abstract:
Chromatin assembly factor I (CAF-I) mutants establish the role of this complex in maintaining silencing at the yeast silent mating loci. The complex does not reestablish silencing as that is done by sir3 cells. This suggests that silencing has two cooperative mechanisms controlling establishment and maintenance.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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