The compulsion of chirality: toward an understanding of left-right asymmetry
Article Abstract:
Molecular mechanisms that orient left-right (LR) axis in embryos have been unknown. It has been shown recently that the inverted viscerum mutation in mice may come from a mutation in a gene that encodes an axonemal dynein heavy chain. Along with answers, this has brought new questions: what the role of axonemal dynein is as opposed to that of cytoplasmic dynein and how dynein action is moved across fields of cells. Timing of initial LR actions in embryogenesis and evolutionary functions of asymmetry are of interest.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
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Wnt antagonism initiates cardiogenesis in Xenopus laevis
Article Abstract:
Results demonstrate that expression of the Wnt antagonists Dkk-1 and Cresent are capable of inducing heart formation in noncardiogenic ventral marginal zone mesoderm of Xenopus laevis. Data indicate that diffusion of Dkk-1 and Cresent from the Spemann region initiates cardiogenesis by reducing the activity of inhibitors Wnt3A and Wnt8.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex
Article Abstract:
The role of Wnt antagonists in heart induction is studied with reference to Xenopus, where Wnt antagonists stimulate cardiogenesis non-cell autonomously. The results indicate that homeodomain transcription factor Hex plays an important role in heart induction by Wnt antagonists.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
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