The dual-role of Fas-ligand as an injury effector and defense strategy in diabetes and islet transplantation

Article Abstract:

The intrinsic sensitivity of beta cells to Fas-Fas-ligand (FasL)-mediated apoptosis, the condition underlying the beta cell sensitivity, and the feasibility of using FasL to arrest autoimmunity and prevent islet allograft rejection is discussed. The results in both the autoimmune and transplant setting revealed that it is imperative to progress from the administration of nonspecific immunosuppressive therapy to the concept of beta-cell-specific immunomodulation.

Islands of Langerhans, Islets of Langerhans, Pancreatic beta cells, Pancreatic beta cell transplantation

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Magnetoreception

Article Abstract:

Two hypotheses are currently being discussed for magnetoreception, one proposing magnetite-based mechanism, the other suggesting radical pair processes involving photopigments. The findings suggest that, in birds, a radical pair mechanism located in the right eye provides directional information for a compass, while a magnetite-based mechanism located in the upper beak records magnetic intensity, thus providing positional information.

Physiological aspects, Birds, Magnetite, Bird navigation

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NMDA receptors expressed in oligodendrocytes

Article Abstract:

The study demonstrates that NMDA receptor is expressed in oligodendrocytes and NMDA receptors might play a role in ischaemia, providing new clues in myelination field. NMDA receptors, a subtype of glumatate receptors are vital to the remodeling of synaptic connections during postnatal development and associative learning abilities in adults and possibly in improvements in oligodendrocyte function.

New York, Central nervous system, Neural transmission, Synaptic transmission, Properties, Methyl aspartate, N-methyl-D-aspartate

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