The emerging tree of west Eurasian mtDNAs: a synthesis on control-region sequences and RFLPs
Article Abstract:
An analysis based on two systems for describing the human mitochondrial genome (mtDNA) has been carried out using 95 samples from the Near East and northwest Caucasus. One procedure is assaying restriction fragment length polymorphisms (RFLPs) all through the genome and the other is sequencing of parts of the control region (CR). The concordance of the two systems has been demonstrated. Variation in mtDNA is used to infer histories of peoples. The most refined phylogeny so far found for west Eurasian mtDNA has been presented and a nomenclature described and applied for mtDNA clusters. Hypervariable nucleotides have been identified. Relative mutation rates of the two systems have been evaluated with ambiguities identified. Berber speakers were sampled and a identification of signature mutations for each cluster led to a hierarchical scheme for finding cluster composition. The main indigenous North African cluster is a sister group to the most ancient cluster of European mRNAs. It diverged about 50,000 years ago.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1999
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A mitochondrial stratigraphy for Island Southeast Asia
Article Abstract:
The two-tier population history of Island Southeast Asia (ISEA) is refuted by demonstrating that mitochondrial DNA diversity in the region is extremely high and includes a large number of indigenous clades. The movement and expansion of indigenous mtDNA lineages, studied through coding-region and control-region variants obtained from complete sequence data, suggest that the prehistory of the region has to be rethought.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
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mtDNA analysis reveals a major late Paleolithic population expansion from southwestern to northeastern Europe
Article Abstract:
mtDNA analysis shows that a significant population expansion from southwestern Europe into northeastern Europe took place during the Late Paleolithic, about 10,000-15,000 years ago. Haplogroup V acts as an mtDNA marker of the expansion, while haplogroup H also was spread. Other genetic evidence supports the expansion. Nine Eurasian populations, a total of 419 individuals, were studied for the mtDNA analysis.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1998
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