Two enzymes, both of which process recombination intermediates, have opposite effects on adaptive mutation in Escherichia coli

Article Abstract:

A study of Escherichia coli bacteria undergoing lac- mutations was conducted to identify possible unique processes involved in the mutations. The results identified RuvAB and RecG as two enzymes responsible for translocating Holliday junctions. It was revealed that the two enzymes, which process recombination intermediates, are also involved in the mutagenic process and have opposite effects. RuvAB controls RecA-dependent adaptive mutations while RecG inhibits such mutations.

Physiological aspects, Escherichia coli, Enzymes

---

Molecular analysis of lambda bio transducing phage produced by oxolinic acid-induced illegitimate recombination in vivo

Article Abstract:

Oxolinic acid, which inhibits DNA gyrase, accelerates the formation of lamda Spi(super -) phages brought about by two variants of a DNA gyrase-dependent mechanism. Illegitimate recombination was observed between regions of short homology in prokaryotes and eukaryotes. The sites of cleavage and recombination show similarities indicating DNA gyrase, showing that the mammalian topoisomerase II can bind to and cleave DNA involved in illegitimate recombination.

Observations, DNA topoisomerase II

---

Similar abstracts:

• Abstracts: The evolution of tandemly repetitive DNA: recombination rules. Active mutator elements suppress the knotted phenotype and increase recombination at the Kn1-0 tandem duplication
• Abstracts: Mechanism of action of regulatory proteins encoded by complex retroviruses. part 2 The Rhizobium-plant symbiosis
• Abstracts: Contrasting roles of interallelic recombination at the HLA-A and HLA-B locus
• Abstracts: How small are smallest selectable domains of form? Multiple paternity and genomic imprinting

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.