Contrasting roles of interallelic recombination at the HLA-A and HLA-B locus
Article Abstract:
The rates of intralocus recombination were quantified by statistical analysis of DNA sequences of human HLA-A and HLA-B class I MHC loci. Recombination occurred twice as frequently at the B locus than the A locus with B locus recombinants significantly affecting polymorphic sites in the antigen recognition sites. Well-defined allelic lineages in the A locus seem to have persisted prior to the human-chimpanzee divergence in contrast to the B locus. Thus, relatively frequent interallelic recombination has been a feature of long-term evolution of the B locus.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
Hot spots of recombination in fission yeast: inactivation of the M26 hot spot by deletion of the ade6 promoter and the novel hotspot ura4-aim
Article Abstract:
The M26 mutation is widely recognized as a meiotic recombination hot spot in Schizosaccharomyces pombe. The hot spot, also a single base substitution, is located within the ade6 open reading frame near the 5' end. Although M26 accounts for both homologous and ectopic recombination in meiosis, it fails to catalyze mitotic recombination. An active M26 decreases activity for the ura4-aim novel recombination hot spot.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Somatic and germinal recombination of a direct repeat in Arabidopsis. Soybean resistance genes specific for different Pseudomonas syringae avirulence genes are allelic, or closely linked, at the RPG1 locus
- Abstracts: A method of screening for genes of major effect. Genetic variation and random drift in autotetraploid populations
- Abstracts: Protists as Indicators of Pollution. Ward's Smart Slides: Animal and Plant Mitosis Study Set. Gene Jockey: Sequence Processor
- Abstracts: Straw compost and bioremediated soil as inocula for the bioremediation of chlorophenol-contaminated soil. Interactions between marine bacteria and dissolved-phase and beached hydrocarbons after the Exxon Valdez oil spill
- Abstracts: Regulatory autonomy and molecular characterization of the Drosophila out at first gene. Flamenco, a gene controlling the gypsy retrovirus of Drosophila melanogaster