The ihog cell-surface proteins bind hedgehog and mediate pathway activation
Article Abstract:
The ihog gene (interference hedgehog), identified by RNA interference in Drosophila cultured cell, encodes a type 1 membrane protein to bind and to mediate response to the active Hedgehog (Hh) protein signal. Other members of the ihog family also interact with Hh ligands via a specific fibronectin type III domain, thus identifying an evolutionary conserved family of membrane proteins that function in Hh signal response.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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By binding SIRPalpha or calreticulin/CD91, lung collectins act as dual function surveillance molecules to suppress or enhance inflammation
Article Abstract:
Results demonstrate that lung collectins surfactant protein A and D facilitate maintaining a non/anti-inflammatory lung environment via stimulation of SIRPalpha on resident cells. The interaction of SIRPalpha globular head domain with pathogen associated molecular patterns on alien organisms and aggregation of the collagenous tail domains to calreticulin/CD91 stimulate phagocytosis and proinflammatory responses.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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