The ATP-dependent PIM1 protease is required for the expression of intron-containing genes in mitochondria

Article Abstract:

The ATP-dependent PIM1 protease performs several essential functions during gene expression in the mitochondria of yeast. Without PIM1, cells lack respiratory competence because lesions accumulate in the mitochondrial DNA (mtDNA). A multicopy suppressor has been identified which allows stabilization of mtDNA while PIM1 is absent, enabling study of PIM1 protease's functions in mitochondrial biogenesis. PIM1 protease is involved in synthesis of cytochrome c oxidase subunit I and of cytochrome b, which affect respiratory chain biosynthesis.

Proteases, Mitochondria, Adenosine triphosphate, ATP, Tissue respiration, Introns, Cytochromes

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Crystal structures of the ribosome in complex with release factors RF1 and RF2 bound to a cognate stop codon

Article Abstract:

The crystal structures of the ribosome from Thermus thermophilus with RF1 and RF2 bound to their cognate stop codons, at resolutions of 5.9 Angstrom and 6.7 Angstrom, respectively are presented. The feasibility of crystallizing ribosomes with bound factors at a define state along the translational pathway is demonstrated.

Science & research, Genetic aspects, Bacteria, Thermophilic, Ribosomes, Genetic research, Thermophiles

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