The left-right coordinator: the role of Vg1 in organizing left-right axis formation
Article Abstract:
A study was conducted to propose a model in which a left-right coordinator interacts with the Spemann organizer to coordinate the evolutionarily conserved three-dimensional asymmetries in the embryo. It was found that the Vg1 cell-signalling pathway plays an important role in left-right coordinator function. Also, cell-lineage directed expression of Vg1 can fully invert the left-right axis, can randomize left-right asymmetries or can rescue a perturbed left-right axis in conjoined twins to normal orientation, indicating that Vg1 can mimic left-right coordinator activity.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
Axon guidance: a compelling case for repelling growth cones
Article Abstract:
The nervous system is an extensive assembly of neurons, which receive, integrate and respond to various signals coming from the environment. The production and propagation of signals are influenced by the behavior of growth cones, which are located at the distal tip of the axon. Previous studies have shown that growth cone behavior and axon navigation are dependent on the identity of the proteins transmitting the environmental signals. The influence of two protein families, semaphorins/collapsins and netrins, on growth cone behavior are discussed.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Axis formation in plant embryogenesis: cues and clues
Article Abstract:
Primary meristems of the shoot and the root play key roles in the development of adult plants. Unlike pattern formation in animals, plant development passes through various embryonic stages before the adult form is reached. The central and peripheral zones in the meristems add new structures to produce secondary roots and leaves. Continuous expression of genes establishes the primary meristems of the shoot and root in the embryo, which eventually leads to body organization of the seedling.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Using experimental manipulation to assess the roles of leaf litter in the functioning of forest ecosystems. A complete phylogeny of whales, dolphins and even-toed hoofed mammals (Cetartiodactyla)
- Abstracts: Eighty years in the making. To build a killing machine. Juan Rivera
- Abstracts: Plant invasions - the role of mutualisms. Pollen and seed dispersal among dispersed plants. The role of frugivorous bats in tropical forest succession
- Abstracts: The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection
- Abstracts: Melanin and the abrasion resistance of feathers. Nutrient-reserve dynamics of breeding male wood ducks. Filter feeding in flamingos (Phoenicopterus ruber)