The mammalian Mre11-Rad50-Nbs1 protein complex: integration of functions in the cellular DNA-damage response

Article Abstract:

Integration of functions in the cellular DNA-damage response has been examined in the mammalian Mre11-Rad50-Nbs1 protein complex. Formation of double-strand breaks (DSBs) is necessary for initiation of programmed DNA recombination events, among them immunoglobulin-gene recombination, meiotic exchange and mating-type switching. But DSB formation and repair often bring pathological outcomes. A complex network of functions is responsible for the great stability of genetic information. A detector of DSBs that will transduce a signal that the lesion has arisen is required. Nijmegen breakage syndrome, the RAD52 epistasis group in yeast, cell-cycle checkpoints, genomic instability and malignancy and recombinational DNA repair are discussed.

United States, Physiological aspects, DNA repair, Ultraviolet radiation, Cancer, Cancer genetics, Yeast, Yeast (Food product), Genetic disorders, Mammals, Infrared radiation

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The Rad50(super s) allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: Implications for the Mre11 complex as a DNA damage sensor

Article Abstract:

An Ataxia-Telangiectasia Muted (ATM)- and Chk2-deficient Rad50(super s/s) mice are generated and it is found that Rad50(super s/s) cellular attrition is strongly ATM and Chk2 dependent. It is also suggested that the Rad50(super s) allele is hypermorphic for DNA damage signaling, and that the resulting constitutive low-level activation of the DNA damage response accounts for the partial suppression of ATM deficiency in Rad50(super s/s) ATM(super -/-) mice.

Allelomorphism, Alleles, Genetic research

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Molecular cross-talk among chromosome fragility syndromes

Article Abstract:

Researches have led to the conviction that the pathways involved in many chromosome fragility syndromes converge in a common tumor suppression nuclear network of interactions. An International Workshop was organized to further characterize how the various proteins involved in these syndromes are interconnected.

Tumor suppressor genes, Chromosomes, Tumour suppressor genes

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