The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease
Article Abstract:
The neuroendocrine protein 7B2 was examined with respect to the role it plays in the activation of prohormone convertase 2 (PC2). Using a novel transposon-based method, 7B2 null mice were generated and were discovered to lack PC2 activity. They were also found to have multiple metabolic derangements that were similar to those found in PC2 null mice. Results also showed that 7B2 null mice developed and died of Cushing's disease, with multiple sequelae of hypercorticosteronism. This seems to indicate a novel role for 7B2 in the control of peptide secretion from the pituitary gland.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
Article Abstract:
A yeast genetic selection system identified Fas and a 74 kDa protein, designated RIP, which are two gene products that interact with the Fas cytoplasmic domain. RIP interacted weakly with the intracellular domain of TNFR1, but was susceptible to murine Ipr mutation. Overexpression of RIP caused transfected cells to undergo morphological changes characteristic of apoptosis. These results suggest that RIP induces cell death by acting as an apoptosis-inducing protein.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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cul-1 Is required for cell cycle exit in C. elegans and identifies a novel gene family
Article Abstract:
The cul-1 gene, or cullins, belongs to a conserved family of genes that has at least five members in nematodes, six in man and three identified in budding yeast. Functional studies indicate that the gene is a regulator of the cell cycle in Caenorhabditis elegans. The expression of the cul-1 gene overrides cellular control mechanisms which regulate G1 to S-phase progression and shunts the pathway toward apoptosis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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