The retinoblastoma protein and cell cycle control
Article Abstract:
The retinoblastoma tumor suppressor gene produces the pRB protein which controls the interaction of the cell cycle clock with transcription in the cells. Phosphorylation of pRB makes it inactive and the cell cycle continues after the G1 phase of the cell cycle. In many cancerous cells the pRB becomes inactive because of mutations and can no longer control the cell divisions. However for many cells to differentiate it is necessary for pRB to become inactive and the tissues containing cells which do not possess an active pRB undergo apoptosis and the defective cells are lost.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Rescue of cyclin D1 deficiency by knockin cyclin E
Article Abstract:
A study was conducted to analyze a mouse strain in which the coding sequences of the cyclin D1 gene have been deleted and replaced by those of human cyclin E. The replacement of cyclin D1 with cyclin E rescues all phenotypic manifestations of cyclin D1 deficiency and restores normal development in cyclin D1-dependent tissues. Results indicated that cyclin E can functionally replace cyclin D1 and that it is the major downstream target of cyclin D1.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA
- Abstracts: Physical interaction of the retinoblastoma protein with human D cyclin. Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
- Abstracts: Cosuppression in Drosophila: gene splicing of Alcohol dehydrogenase by white-Adh transgenes is Polycomb dependent
- Abstracts: A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm. Lumenal proteins of the mammalian endoplasmic reticulum are required to complete protein translocation
- Abstracts: Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos. Attraction versus repulsion: modular receptors make the difference in axon guidance