(CA/GT)(sub.n) microsatellites affect homologous recombination during yeast meiosis
Article Abstract:
(CA/GT)(sub.n) microsatellites have an effect on yeast meiosis homologous recombination. Behavior of a region of the Saccharomyces cerevisiae genome containing a 39-CA/GT dinucleotide repeat sequence has been studied. Meiotic instability of the microsatellite was very high in all spores with recombinant and parental chromosomes, a surprise.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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The set1(Delta) mutation unveils a novel signaling pathway related by the Rad53-dependent hyperphosphorylation of replication protein A that leads to transcriptional activation of repair genes
Article Abstract:
Constitutive MEC1/TEL1-independent hyperphosphorylation of Rfa2p is brought on by inactivation of Set1p in a process requiring Rad53p. A pathway that shows why Set1p inactivation raises repair capabilities of the cell when checkpoints fail has been documented. The response is unlike the MEc1-dependent DNA damage induction pathway.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the Ligase IV pathway
Article Abstract:
Nonhomologous end-joining (NHEJ) regulation by mating type in Saccharomyces cerevisiae has been found to work, at least in part, through a novel protein required for the Ligase IV pathway, Lif2p. DNA double-strand break (DSB) repair by NHEJ has been studied.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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