The store-operated calcium current Icrac: nonlinear activation by InsP3 and dissociation from calcium release
Article Abstract:
A research on the relationship of intracellular Ca2+ release and activation of store-operated calcium current Icrac is done. The experiment has shown that agonist and InsP3-mediated activation of Icrac are nonlinear that is transpiring above a narrow concentration range. Ca2+ release and influx have differential sensitivities to InsP3 which separate the two. As a proof, low concentrations of InsP3 cause enough Ca+ release without any activation of Icrac, however, such concentrations of InsP3 are enough to start Ca2+ influx.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils
Article Abstract:
Research has been conducted on neutrophil. The ability of this neutrophil to polarize in chemoattractant's uniform concentration and its U-turn response to the attractant gradient reversal have been investigated, and the results are reported.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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