The structural basis for regulated assembly and function of the transcriptional activator NtrC
Article Abstract:
X-ray solution scattering and electron microscopy structures of the activated, full-length nitrogen regulatory protein C (NtrC) is reported, showing a novel mechanism for regulation of AAA+ ATPase assembly via the juxtaposition of the receiver domains and ATPase ring. Accompanying the hydrolysis cycle that is required for transcriptional activation, major order-disorder changes in the GAFTGA loops involved in the sigma(super 54) binding as well as in the DNA-binding domains are observed.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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The species-specific egg receptor for sea urchin sperm adhesion is EBR1, a novel ADAMTS protein
Article Abstract:
Research has been conducted on species-specific egg bindin receptor from sea urchins. The authors describe the identification and characterization of this receptor, and they report that the recombinant species-specific egg bindin receptor and hyalin-like repeats are species-specific ligands for the sperm adhesive protein bindin.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
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- Abstracts: Localized recruitment of a chromatin-remodeling activity by an activator in vivo drives transcriptional elongation
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