The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs
Article Abstract:
A study was conducted to analyze the crystal structure of the protein phosphatase 2A PR65/A subunit that functions as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Experimental results indicated that members of the protein family share a common architecture. Findings also showed that additional structural diversity could be produced by the sequence insertions between adjacent motifs.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Yeast prions and their prion-forming domain
Article Abstract:
This article discusses the nature of inheritance of stable phenotypic traits in yeast in a non-Mendelian fashion. Yeast prions replication mechanisms are discussed in the context of mammalian protein prions to point out that unlike the latter yeast prions are not infectious agents.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
The crystal structure of human eukayotic release factor eRF1-mechanism of stop codon recognition and peptidyl-tRNA hydrolysis
Article Abstract:
Results indicate that the GGQ sequence motiff on the release factor eRF1 triggers the hydrolytic activity of the peptidyl transferase complex. Data further show that substitutions of glycine residues in the motiff abolishes this activity of the eRF1.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Structure of the Y chromosomal Su(ste) locus in Drosophila melanogaster and evidence for localized recombination among repeats
- Abstracts: The transfer of left-right positional information during chick embryogenesis. Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton
- Abstracts: The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin
- Abstracts: Principles of viral pathogenesis. Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development