Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha
Article Abstract:
A very powerful procedure was used to find what happens when HNF-4alpha function is absent in liver development, and it was found that mammalian hepatocyte differentiation must have the this transcription factor. Mouse embryos die if they have no HNG-4alpha, but they were rescued by complementation with a tetraploid embryo-derived wild-type visceral endoderm.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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BMPs on the road to hepatogenesis
Article Abstract:
Bone morphogenic proteins (BMPs) and their contribution to hepatogenesis are discussed in this perspective article. BMPs secreted from septum transversum mesenchyme are needed together with cardiac-derived fibroblast growth factors (FGFs) to cause the ventral endoderm to have a hepatic fate. Recent breakthroughs have brought up new questions.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle
Article Abstract:
The transcriptional repressor, CCAAT displacement protein (CDP) (Cutl1), has been found to be necessary for epithelial cell differentiation of the hair follicle and the lung. The C-terminal Cut repeat 3 and homeodomain exons were replaced with an in-frame lacZ gene by targeted mutagenesis in mice for the study.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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