Translation by ribosome shunting on adenovirus and hsp70 mRNAs facilitated by complementarity to 18S rRNA

Article Abstract:

Ribosome shunting on adenovirus and hsp70 mRNAs is discussed. Translation by this means is facilitated by 18S rRNA complementarity. A study has shown that the 5' noncoding region of human adenovirus late mRNAs, known as the tripartite leader is a factor. It seems ribosome shunting may involve specific RNA structural features or a prokaryotic-like interaction between mRNA and rRNA.

United States, Genetic aspects, DNA, Ribosomal RNA, Cytochemistry, Ribosomes, Adenoviruses, Human, Human adenoviruses

---

Tethering of eIF4G to adenoviral mRNAs by viral 100k protein drives ribosome shunting

Article Abstract:

A molecular mechanism for ribosome shunting is described. Mutational and biochemical studies show that the ability of 100k protein to bind tripartite leader and eIF4G are critical to promote a high level of ribosome shunting.

Gene mutations, Gene mutation, Ribosomal proteins

---

Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs

Article Abstract:

An AUF1 knockout mouse is developed to understand the function of the AU-rich element (ARE)-binding protein AUF1. The results have provided the first in vivo evidence implicating AUF1 in regulation of the inflammatory response and they have provided a molecular understanding of AUF1 action in selective targeted degradation of inflammatory cytokine mRNAs.

Septic shock, Tumor necrosis factor, Structure, Tumour necrosis factor, Report

Similar abstracts:

• Abstracts: Oxygen regulation of airway branching in Drosophila is mediated by Branchless FGF. Ras1 promotes cellular growth in the Drosophila wing
• Abstracts: Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Secondary structure of vertebrate telomerase RNA
• Abstracts: Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation. The Drosophila Shark tyrosine kinase is required for embryonic dorsal closure
• Abstracts: Clostridium difficile cell attachment is modified by environmental factors. A Clostridium difficile gene encoding flagellin
• Abstracts: The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.