The value of molecular haplotypes in a family-based linkage study
Article Abstract:
A simulated study is used to compare the value of molecular haplotypes with the power of using standard genotyping in the context of a family-based linkage study. The results indicate that most of the increase in power is achieved by molecularly haplotyping a single individual in each family, thereby making it a valuable strategy for increasing the power of gene mapping studies of complex diseases.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Association mapping via regularized regression analysis of single-nucleotide-polymorphism haplotypes in variable-sized sliding windows
Article Abstract:
A new approach for haplotype association analysis is proposed to tackle the problem of multiple degrees of freedom in the haplotype test. A large number of haplotypes could be handled by the method in association analyses more efficiently and effectively than do currently available approaches.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to Schizophrenia
Article Abstract:
Random markers on chromosome 11q22-24 were initially selected for fine mapping and confirmation was performed by the study of an Aberdeen sample. The strongest allelic and haplotypic associations were found with markers within FXYD6 gene.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The art of the tech transfer deal. Biotech patents under fire. Why patents troll threaten biotech
- Abstracts: The chief of bioethics. The plural of anecdote is not ambien. The kevorkianization of Dolly
- Abstracts: The art of the tech transfer deal. Dealing with conflict
- Abstracts: EST databases as a source for molecular markers: Lessons from Helianthus. Chloroplast DNA variation confirms a single origin of domesticated sunflower (Helianthus annuus L.)
- Abstracts: Boning up on ephrin signaling. The molecular clock mediates leptin-regulated bone formation. The Ephrin VAB-2/EFN-1 functions in neuronal signaling to regulate epidermal morphogenesis in C. elegans