Transcription factor SIX5 is mutated in patients with branchio-oto-renal syndrome

Article Abstract:

Mutations in SIX5 are identified as a novel cause of BOR. Results reveal that mutations of SIX5 compromise the interaction between the two proteins decreasing the transcriptional activity of the Eya1-SIX5 complex.

Gene mutations, Gene mutation, Genetic transcription, Transcription (Genetics), Report, Branchio-Oto-Renal syndrome

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Eya1 regulates the growth of otic epithelium and interacts with Pax2 during the development of all sensory areas in the inner ear

Article Abstract:

The role of eyes absent 1 (Eya1) genes in the development of epithelium and sensory regions of the inner ear in mice is studied.

Sweden, Mice, Growth, House mouse, Epithelium, Labyrinth (Ear), Company growth

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Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1

Article Abstract:

The role that Six genes and Eya1 play in the development of the third pharyngeal pouch into the thymus/parathyroid is studied.

Developmental genetics, Thymus, Thymus gland, Pharynx, Throat, Parathyroid glands

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