Translational recoding induced by G-rich mRNA sequences that form unusual structures
Article Abstract:
Participatory sequences in the herpes simplex virus thymidine kinase (HSV tk) recoding are determined in a herpesvirus mutant. The findings demonstrate a novel mechanism that relies on the capacity of the G-rich sequences to generate unique inter- or intramolecular structures. Specifically, the sole influence of G-strings to activate a net +1 recoding in cultured cells is determined. On the other hand, mediation of recoding by the G-string structure inside the ribosome is proposed to proceed either by the Hoogsteen or non-Watson-Crick interactions.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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A segmentation gene in Tribolium produces a polycistronic mRNA that codes for multiple conserved peptides
Article Abstract:
A new member of the gap family of segmentation genes in the flour beetle Tribolium, mille-pattes (mlpt) is described, showing that there are cross-regulatory interactions between mlpt and the known gap genes in Tribolium, suggesting that mlpt is itself a gap gene. The mltp gene reveals an unusual structure, as it encodes a polycistronic messenger ribonucleic acid (mRNA) that codes for four peptides.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
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