Transmembrane topology of the two FhuB domains representing the hydrophobic components of bacterial ABC transporters involved in the uptake of siderophores, haem and vitamin B
Article Abstract:
Ferric hydroxamate transport throughout the Escherichia coli outer membrane is energy dependent. A topology model of the involvement of an integral cytoplasmic membrane protein in bacterial iron uptake is presented. The amino acid sequences of the equivalent siderophore-transport related PBT proteins from both Gram-positive and negative bacterial, showed a distinct polypeptide class which may have similar transmembrane organization. The model protein FhuB differs significantly in some areas from topology models of most other PBT-related hydrophobic proteins.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1998
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Phenotypic variation in Actinobacillus actinomycetemcomitans during laboratory growth: implications for virulence
Article Abstract:
A study was conducted to analyze the alteration of specific virulence traits related to phenotypic changes seen when a low-passage disease-associated and well maintained parent strain of Actinobacillus actinomycetemcomitans was compared against a laboratory-growth spontaneous variant/mutant. Results indicated that clinical isolates of A actinomycetemomitans undergo virulence-reducing phenotypic alterations during in vitro passage.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1999
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