Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysis

Article Abstract:

Research has been conducted on the cell differentiation and morphogenesis in multicellular organisms. The experiments with the cell cycle regulator have been carried out.

Statistical Data Included, Analysis, Morphogenesis, Cell research, Cytological research

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Guidance of cell migration by the Drosophila PDGF/VEGF receptor

Article Abstract:

Research shows that a tyrosine kinase receptor, related to mammalian PDGF and VEGF receptors, function as a guidance factor and directs cell migration to the oocytes in vivo. Data are presented implicating Rac and Rac activator functioning as mediators of this guidance signal.

Physiological aspects, Cellular signal transduction, Protein tyrosine kinase, Protein-tyrosine kinase, Cell receptors, Cell migration

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Cyclin ubiquitination: the destructive end of mitosis

Article Abstract:

Ubiquitin-mediated proteolysis destroys cyclin B2 and enables the cell to leave mitosis. This destruction of cyclin B induces transition from metaphase to anaphase. Cyclin B has a short terminal sequence of amino acids, termed the destruction box, that eventually causes the destruction of cyclin B. A similar mechanism seems to be involved in sister chromosome separation. The destruction of cyclin B by ubiquitination is regulated by E2 and E3 enzymes. Genes in the family of cdc16 and cdc23 are involved in stabilizing and destroying cyclin B. Cell cycle regulation apparently takes place at the level of cyclin B, as well as through ubiquitinating enzymes.

Ubiquitin

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