Relief of gene repression by Torso RTK signaling: role of capicua in Drosophila terminal and dorsoventral patterning
Article Abstract:
The role of capicua in Drosophila dorsoventral and terminal patterning is discussed relative to relief of gene repression by Torso (Tor) receptor tyrosine kinase (RTK) signaling. A new gene, cic, one which acts as a repressor of terminal genes regulated by the Tor pathway and mediates repression along the dorsoventral axis has been identified. The gene also encodes an HMG-box transcription factor that interacts with Gro in vitro. Evidence that Tor signaling regulates terminal patterning by inactivating Cic at the embryo poles has been found. Cic-like proteins may act as repressors regulated by RTK signaling in other organisms.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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Specific tracheal migration is mediated by complementary expression of cell surface proteins
Article Abstract:
Specific tracheal migration has been found to be mediated by complementary expression of cell surface proteins. The role of cell adhesion receptors of the integrin family in the definition of a migratory pathway in Drosophila has been studied.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
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The RhoGAP corssveinless-c links trachealess and EGFR signaling to cell shape remodeling in Drosophila tracheal invagination
Article Abstract:
Tracheal cell behavior at vagination is described and it is shown that it is associated with, and requires, a distinct recruitment of Myosin II to the apical surface of cells at the invaginating edger. The results identify a developmental pathway linking cell fate genes and cell signaling pathways to intracellular modifications during tracheal cell invagination.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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