Characterization of the low-pH responses of Helicobacter pylori using genomic DNA arrays

Article Abstract:

The ability of Helicobacter pylori to survive an acidic environment is mediated by expression or down-regulation of genes in response to the low-pH environment of the human stomach. Data reveal that cagA gene and genes encoding lipopolysaccharide, phospholipids, and a protein-export component are induced and three other genes down-regulated.

Statistical Data Included, Environmental aspects, Helicobacter pylori, Cell culture, Tissue culture, Hydrogen-ion concentration

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cDNA-RNA subtractive hybridization reveals increased expression of mycocerosic acid synthase in intracellular Mycobacterium bovis BCG

Article Abstract:

Research shows that a subset of genes are differentially expressed, including the gene encoding mycocerosic acid synthase, after phagocytosis of Mycobacterium bovis by macrophages. Data indicate that five of the expressed genes are up-regulated in M. bovis when inside macrophages.

Methods, Nucleic acid hybridization, Enzymes, Enzyme synthesis, Mycobacterium bovis, Phagocytosis

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