Unique response pathways are established by allosteric interactions among nuclear hormone receptors

Article Abstract:

An examination of the transcriptional properties of nuclear receptors suggested that 9-cis retinoic acid receptors (RXR) possess dual hormonal responsiveness. However, its capability to bind with various nuclear receptors including the thyroid hormone receptor and the retinoic acid receptor are masked in T3R-RXR and RAR-RXR heterodimers. However, RXR has been shown to be more active as a non-DNA-binding cofactor with the NGFI-B/Nurr 1 orphan receptors. These results suggest that allosteric interactions exist among nuclear hormone receptors.

Allosteric proteins

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Identification of a nuclear receptor that is activated by farnesol metabolites

Article Abstract:

Isolation of a heterodimeric complex containing cDNA for an orphan nuclear receptor named farnesoid X-activated receptor revealed that the complex is activated by farnesol and related molecules. Studies on the action of farnesol metabolites in bacteria and yeast suggested that these molecules influence genetic transcription. These results suggest that even higher organisms utilize the signal recognition complex for genetic transcription.

Ligands (Biochemistry)

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15-deoxy-Delta(super 12,14)-prostaglandin J(sub 2) is a ligand for the adipocyte determination factor PPAR(sub gamma)

Article Abstract:

The binding of 15-deoxy-Delta(super 12,14)-prostaglandin J(sub 2) (15d-PGJ(sub 2)) to the peroxisome proliferator-activated receptor gamma isoform (PPAR(sub gamma)) stimulates formation of adipocytes. Thiazolidinediones, antidiabetic drugs, also bind to and activate PPAR(sub gamma). A defect in the 15d-PGJ(sub 2)-PPAR-(sub gamma) signalling pathway, probably, causes the development of noninsulin-dependent diabetes mellitus and obesity.

Physiological aspects, Observations, Prostaglandins, Fat cells, Adipocytes, Cooperative binding (Biochemistry)

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