Unwinding dosage compensation

Article Abstract:

Dosage compensation refers to the regulated expression of genes, ususally on the sex chromosomes, resulting in equivalency of gene product formation in both sexes. In mammals, this may be achieved by X chromosome inactivation in the female soma, while in Drosophila, male X-linked genes are transcribed at twice the level of their female counterparts. Some recent findings in male X expression are presented and discussed.

Research, X chromosome, Dosage compensation (Genetics)

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Trans-sensing effects: the ups and downs of being together

Article Abstract:

Somatic pairing in diploid nuclei involves a variety of genetic and epigenetic phenomena that include allelic and nonallelic interactions. Several models of these phenomena, also known as 'trans-sensing effects,' are used in the study of phenotypic changes in Drosophila. These include transvection, pairing-dependent repression, trans-inactivation, homolog dragging and trans suppression.

Models, Chromosomes

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Bugs on drugs go GAGAAA

Article Abstract:

This review describes the action of a sequence- specific DNA binding compound, which upon binding to the minor groove of a GAGAA-rich repetitive element causes a mutation that leads to the production of GAGA factor (GAF) DNA binding regulatory protein. Results show that Drosophila larvae fed with such compounds undergo homeotic transformations.

United States, Drugs, Physiological aspects, Nucleotide sequence, Base sequence, DNA binding proteins, Structure-activity relationships (Pharmacology), Genetic transformation

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