VNTR allele frequency distributions under the stepwise mutation model: a computer simulation approach
Article Abstract:
A study used computer simulations of the one-stage stepwise mutation model (SMM) to examine four parameters of variable number of tandem repeats (VNTRs), the number of alleles, number of modes, range in allele size and heterozygosity. Short tandem repeats (STR) loci and simulation findings under the SMM were the same for the number of alleles, number of modes and range in allele size. Observed difference related to microsatellite and minisatellite loci system that the three types of loci are exposed to separate mutational influences.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1993
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A class of population genetic questions formulated as the generalized occupancy problem
Article Abstract:
Researchers applied combinatorial methods to the classical occupancy problem to obtain precise sampling distributions of different statistics. This was done to overcome the problem in classified genetic data studies when sampling units are arranged into a tentative number of specific types and the sample size is inadequate to use large sample estimates for examining hypotheses. It is called the generalized occupancy problem because multinominal probabilities are not necessarily equal.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1993
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Multiple alleles and estimation of genetic parameters: computational equations showing involvement of all alleles
Article Abstract:
Genetic analysis of multi-allelic loci generally employs a matrix treatment, which may involve subjectivity because of the deletion of one allele from the analysis. To eliminate this problem, the matrix estimators were reduced to algebraic expressions, resulting in computational equations which require the frequencies of all alleles. The use of these algebraic expressions should make the analysis of allele frequency data easier and numerically more accurate.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1992
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