What have tissue culture studies told us about the development of oligodendrocytes?
Article Abstract:
The bipotential O-2A cell derived from optic nerve tissue cultures may either generate oligodendrocytes or type-2 astrocyte under different conditions. Experiments using antibodies against ganglioside GD3 have pointed to GD3+ cells as oligodendrocyte precursors and in vivo counterparts of the O-2A cells. However, there is still insufficient knowledge about astrocyte phenotypes in vivo and their developmental profile to clearly establish type-2 astrocyte's existence in vivo. Finally, studies indicate that O-2A cells are equivalent to oligodendroblasts described in vivo.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 1992
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mRNPs take shape by CLIPPING and PAIRING
Article Abstract:
The relative strengths and limitations of the three new methods that are designed to identify the RNA-binding proteins (RBP)-RNA interactions are discussed. The development of CLIP, PAIR and trimolecular fluorescence has helped in understanding the RBP-RNA interactions that occur in cells and will thus help define the human interactome.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2006
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