X-chromosome-wide profiling of MSL-1 distribution and dosage compensation in Drosophila
Article Abstract:
Dosage compensation is achieved in Drosophila by a twofold-up-regulation of the male X-linked genes and requires the association of the male-specific lethal complex (MSL) on the X chromosome. A report is presented on the MSL-1-binding profile along the male X chromosome in embryos and male salivary glands isolated from third instar larvae using chromatin immunoprecipitation (ChIP) coupled with DNA microarray (ChIP-chip).
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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Guanosine triphosphate acts as a cofactor to promote assembly of initial P-element transposase-DNA synaptic complexes
Article Abstract:
Protein-DNA complexes formed during the initial stages of P-element transposition is visualized using atomic force microscopy (AFM). The results revealed that guanosine triphosphate (GTP) acts to promote assembly of the first detectable noncovalent precleavage synaptic complex.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
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- Abstracts: Antisense-Mediated depletion reveals essential and specific functions of MicroRNAs in Drosophila development. The developmental miRNA profiles of zebrafish as determined by small RNA cloning