XKlp1, a chromosomal Xenopus kinesin-like protein essential for spindle organization and chromosome positioning

Article Abstract:

A Xenopus kinesin-like protein, XKlp1, is required for the formation of spindles and determines the position of chromosomes. The XKlp1 is in the nucleus at the interphase and in the chromosomes during the process of mitosis. At the anaphase, it develops proteins in the spindle interzone which later on arrange in the midbody at telophase. The XKlp1 amino terminus has a motor domain, and the tail may have a zinc finger-like area.

Analysis, Observations, Xenopus

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Xklp2, a novel Xenopus centrosomal kinesin-like protein required for centrosome separation during mitosis

Article Abstract:

A protein with a structure similar to kinesin was observed in Xenopus cells which directs the formation of mitotic spindles and the segregation of chromosomes during mitosis. The protein Xklp2 has a structure composed of a globular domain at its N-terminal and an alpha-helical tail that ends with the c-terminal. Mutations of both these ends caused a failure in chromosome separation during mitosis and the formation of abnormal spindles.

Microtubules, Kinesin, Protein structure

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Similar abstracts:

• Abstracts: The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anapahase chromosome movement

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