Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease
Article Abstract:
A human homologue of Saccharomyces cerevisiae Rad1 was isolated and tested for possible correcting activity in defects in Xeroderma pigmentosum (XP) F and rodent 4 and 11 cells. Rad1 was able to correct the defects by performing nucleotide excision repair (NER) of the damaged strands. Purification of the XPF protein revealed that NER took place in the 5' region of DNA and that it required a structure-specific DNA repair endonuclease.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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Mammalian DNA nucleotide excision repair reconstituted with purified protein components
Article Abstract:
Mammalian DNA nucleotide excision repair can be reconstituted with purified protein components such as RPA, XPA, TFIIH, XPC, UV-DDB, XPG, partially purified ERCC1/XPF complex, and a new factor called IF7. Nucleoside excision repair is a process by which the body removes DNA damage caused by ultraviolet radiation. Complete repair synthesis involves about 30 polypeptides comprising the 12 reaction components.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK
Article Abstract:
Research has been conducted on the human nucleotide excision repair. The results of the repair synthesis are discussed.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2000
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