The Drosophila E93 gene from the 93F early puff displays stage- and tissue-specific regulation by 20-hydroxyecdysone
Article Abstract:
The study proposes that Drosophila E93 behaves in a stage-specific regulatory hierarchy in the salivary gland to direct its histolysis in reaction to the prepupal ecdysteroid pulse. The initiation of programmed cell death in the salivary gland is immediately preceded by E93 induction. Culturing salivary glands with 20E can induce programmed cell death. The study helps in understanding the molecular mechanism which directs the spatially and temporally controlled development response to ecdysteroids.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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The DHR78 nuclear receptor is required for ecdysteroid signalling during the onset of Drosophila metamorphosis
Article Abstract:
Metamorphosis in Drosophila is controlled by ecdysteroid hormones which prepares the larva for metamorphosis during the third instar. The signal pathway for these hormones is mediated by a nuclear receptor designated as DHR78. Mutant Drosophila that does not express this protein are unable to proceed with ecdysis. It is postulated that this receptor forms a ligand with ecdysteroids and this complex is responsible for the initiation of metamorphosis by regulating puff gene expression.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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Ecdysteroid regulation and DNA binding properties of Drosophila nuclear hormone receptor superfamily members
Article Abstract:
Two Drosophila genes, DHR3 and DHR39, are directly stimulated by the hormone 20-hydroxyecdysone (20E). These genes are members of the Drosophila nuclear hormone receptor superfamily that participates in the metamorphosis from larva to adult fly. Their induction by 20E shows that they are involved in the cascade of hormonal activity during metamorphosis.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 1995
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