AAV does the shuffle

Article Abstract:

A study by Maheshri and group extend error prone PCR and a staggered extension process into the realm of recombination (adeno-associated virus) AAV vectors which not only adds to a rapid growing vector tool kit but also sheds light on structural aspects of the AAV caspid. The study by Maheshri and group is a clear step towards the ultimate goal of engineering AAV vectors tailored to individual patient or disease profiles.

North Carolina, Prevention, DNA synthesis

---

Gene targeting in vivo by adeno-associated virus vectors

Article Abstract:

Adeno-associated virus (AAV) vectors that contain single-stranded DNA can efficiently transduce cells in vivo and are shown to target homologous chromosomal sequences in cultured cells. In order to correct the naturally occurring GusB gene mutation that was responsible for murine mucopolysaccharidosis type VII(super 2) AAV genetargeting vectors are used.

Gene mutations, Gene mutation, Genetic aspects, Rats as laboratory animals, Laboratory rats, Nucleotide sequencing

---

AAV hits the genomic bull's-eye: Adeno-associated virus mediates correction of genetic mutations in mouse liver

Article Abstract:

Hepatic gene correction by adeno-associated Virus (AAV) vectors in vivo is demonstrated, using both a mutant LacZ reporter mouse and a murine model of mucopolysaccharidosis type VII. These studies provide a foundation for the development of AAV vector systems for targeted gene therapy in humans.

Health aspects, Care and treatment, Usage, Gene therapy, Polymerase chain reaction, Mucopolysaccharidosis, Mucopolysaccharidoses, Gene targeting

Similar abstracts:

• Abstracts: Putting the rat on the map. Systemic tumor targeting and killing by Sindbis viral vectors. An archael endoribonuclease catalyzes cis- and trans-nonspliceosomal splicing in mouse cells
• Abstracts: Directed evolution of adeno-associated virus yields enhanced gene delivery vectors. RNAi-mediated replacement of morphine with the nonnarcotic alkaloid reticuline in opium poppy
• Abstracts: An investigation into the measurement of graph distortion in financial reports. The use and representational faithfulness of graphs in Australian IPO prospectuses
• Abstracts: What is the difference between marketing, advertising and PR?
• Abstracts: Protecting the investors' interests. Young enterprise: Learning by doing

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.