Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages
Article Abstract:
The replacement strategy for diabetes involves the clonal isolation of puttative adult pancreatic precursors. The pancreatic cells proliferate in vitro to form clonal colonies that coexpress neural and pancreatic precursor markers, which on identification produce distinct populations of neurons and glial cells, pancreatic endocrine beta, alpha and gamma cells and pancreatic exocrine and stellate cells.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2004
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Telomerase modulates expression growth-controlling genes and enhances cell proliferation
Article Abstract:
The ectopic expression of telomerase in human mammary epithelial cells (HMECs) results in a diminished requirement for exogenous mitogens and this correlates with telomerase-dependent induction of genes that promote cell growth. The telomerase affects proliferation of epithelial cells not only by stabilizing telomeres, but also affects the expression of growth-promoting genes.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2004
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Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling
Article Abstract:
The protein targets of bioactive compounds are determined through the creation of a natural product-inspired small-molecule library bearing protein-reactive elements. Cell-based screening identified a compound, MJE3, which inhibits breast cancer cell proliferation.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
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