Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector
Article Abstract:
A complete 2A peptide-mediated cleavage and stoichiometric production of two fluorescent proteins are presented using a fluorescence resonance energy transfer-based system in multiple cell types including blood, thymus, spleen, bone marrow and early stem cell progenitors. The 2A peptides mediate highly efficient generation of individual CD3 chains in this in vitro translation system.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
Leaders and laggards in the stem cell enterprise
Article Abstract:
Efforts to commercialize stem cell research have survived against long odds, conventional wisdom, and politics and show signs of intelligent life. Even though the US House of Representatives voted to lift restrictions on the federal funding of embryonic stem (ES) cell research, the number of votes were not sufficient to override the promised rejection by President Bush.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Protein chip companies turn to biomarkers
Article Abstract:
Invitrogen, of Carlsbad, California has unveiled its new protein microarray called ProtoArray, which has 1,800 immobilized human proteins. The array contains a cross-section of gene families including proteins that are useful in drug discovery such as kinases, membrane-associated cell signalling and metabolic proteins.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Lockheed Martin confident in Orion21 design. Sikorsky stretches presidential helo cabin. Lockheed Martin confident orion21 will follow P-3
- Abstracts: The competitive implications of multimarket bank branching. Declining required reserves, funds rate volatility, and open market operations
- Abstracts: Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression. Overcoming the gridlock in discovery research
- Abstracts: The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough. Complete genome sequence of the plant commensal Pseudomonas fluorescens Pf-5
- Abstracts: Microarray reality checks in the context of a complex disease. High-affinity binders selected from designed ankyrin repeat protein libraries