Engineered T-cell receptor tetramers bind MHC-peptide complexes with high affinity

Article Abstract:

The tetramerization technology used in T-cell receptors (TCRs) and TCR alphabeta pairs are identified in the absence of accessory molecules that ensure the isolation of high-affinity TCRs that maintain stable binding characteristics after tetramerization. The TCR tetramers facilitate the analysis of the major histocompatibility complex (MHC)-peptide interface and the design of immunotherapeutics and vaccines.

United States, Antigen receptors, T cell, T cell antigen receptors, T cells, MHC antibodies

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Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes

Article Abstract:

The development of the technique for covalent, specific labeling cell surface proteins attached to a 22-amino-acid recognition sequence for Escherichia coli microbial lipoic acid ligase (LpIA) is described. The method gives general access to biochemical and imaging analysis of cell surface proteins, using small fluorphores included through a short peptide tag.

Chemical properties, Thioctic acid

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