Haplotyping in biomedicine--practical challenges

Article Abstract:

The completion of the human genome reference sequence has facilitated human genetics studies of complex traits. However, before the increasing success of searches for genes that predispose for common disease can make a tangible impact on diagnostic, preventive or therapeutic strategies, there are several challenges that need to be met.

Editorial, Human genetics, Haplotypes

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Programmable ligand-controlled riboregulators of eukaryotic gene expression

Article Abstract:

The design of a class of small trans-acting RNAs that directly regulate gene expression in ligand-dependent manner is described. These allosteric riboregulators offer flexible control strategies by adopting active or inactive forms in response to ligand binding, depending on their design.

Cellular control mechanisms, Cell regulation, Ligands (Biochemistry)

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Engineered riboregulators enable post-transcriptional control of gene expression

Article Abstract:

The engineered riboregulators provide a clear vision into the mechanistic actions of endogenous procedures that rely on RNA and can also provide a machinery of biological networks that could be measured. The RNA's have a multipurpose usage and they can perfect control of gene expression.

Causes of, Control, Genetic transcription, Transcription (Genetics), Mechanism (Philosophy)

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