High-resolution computational models of genome binding events
Article Abstract:
A joint binding deconvolution (JBD) method that used additional easily obtainable experimental data regarding chromatin immunoprecipitation (ChIP) to improve the spatial resolution of the transcription factor binding location inferred from chip followed by DNA microarray hybridization data is described. Results show that positional priors allow computational discovery of the Mig2 motif on the failure of the standard approach.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2006
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A bacterial one-hybrid system for determining the DNA-binding specificity of transcription factors
Article Abstract:
A bacterial one-hybrid system that provides a simple and rapid method to determine the deoxyribonucleic acid (DNA)-binding specificity of a transcription factor is described in a study. The technology is successfully used to determine the DNA-binding specificity of seven previously characterized transcription factors and one novel transcription factor.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
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A microengraving method for rapid selection of single cells producing antigen-specific antibodies
Article Abstract:
A soft lithographic method based on intaglio printing to generate microarrays comprising the secreted products of single cells is presented. These engraved arrays enable a rapid and high-throughput system for identification, recovery and clonal expansion of cells producing antigen-specific antibodies.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2006
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