Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts
Article Abstract:
In order to introduce regions of human chromosomes greater than a megabase into cells of animals, the researchers developed a chromosome-cloning system in which defined regions of human chromosomes can be cloned into a stable human minichromosome vector in homologous recombination-proficient chicken DT40 cells.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2000
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Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts
Article Abstract:
In order to introduce human chromosomes greater than a magabase into cells of animals, the researchers developed a chromosome-cloning system in which defined regions of human chromosomes can be cloned into a stable human minichromosome vector in homologous recombination-proficient chicken DT40 cells.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Production of cattle lacking prion protein
Article Abstract:
The generation and characterization of prion protein Pr[P.sup.C]-deficient cattle produced by sequential gene-targeting system is presented. Brain tissue homogenates are resistant to prion propagation in vitro as assessed by protein misfolding cyclic amplification and Pr[P.sup.C]-deficient cattle might be a useful model for prion research and might provide industrial bovine products free of prion proteins.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2007
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