Nanospheres for DNA separation chips
Article Abstract:
A new approach that uses nanoparticle medium, core-shell type nanospheres, in conjunction with a pressurization technique during electrophoresis, for carrying out separations of a wide range of deoxyribonucleic (DNA) acid fragments with high speed and high resolution is described. It can be concluded that the nanosphere system is capable of readily separating DNA fragments over a wide range of sizes with high speed than the conventional methods.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2004
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Large-scale genotyping of complex DNA
Article Abstract:
A simple but effective approach termed whole genome sampling analysis (WGSA), for genotyping thousands of SNPs simultaneously in a complex DNA sample without locus-primers or automation is presented. The conclusion states that WGSA is highly scaleable and enables the creation of ultrahigh density SNP maps for use in genetic studies.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2003
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Multiplexed detection of pathogen DNA with DNA-based fluorescence nanobarcodes
Article Abstract:
The synthesis of dendrimer-like DNA-based, fluorescence-intensity-coded nanobarcodes, which contain a built-in code and a probe for molecular recognition, is demonstrated. Their application to multiplexed detection of the DNA of several pathogens is shown using fluorescence microscopy and dot blotting.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
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