On the iTRAQ of kinase inhibitors
Article Abstract:
A new proteomics method based on kinobeads for quantitatively analyzing the on- and off-target effects of kinase inhibitors is discussed. The iTRAQ reagent is found to highly affect the binding affinities of these kinase inhibitors.
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2007
United States, Mass Spectrometers & Spectroscopy, Mass Spectrometers, Research, Usage, Protein binding, Phosphotransferases
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2007
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Rapid identification of DNA-binding proteins by mass spectrometry
Article Abstract:
Researchers from Denmark and Germany used matrix-assisted laser desorption/ionization time-of-flight mass spectometry to identify DNA-binding proteins isolated from cell extracts conjugated onto small, paramagnetic particles.
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 1999
Denmark, Germany, Drugs, Cellular Protein, In-Vitro Diagnostic Substance Manufacturing, Ion Mass Spectroscopy, Cellular proteins, Mass spectrometry
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 1999
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