Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs
Article Abstract:
A study examines the efficacy of lipid-encapsulated, chemically modified short interfering ribonucleic acid (siRNA) targeted to hepatitis B virus (HBV) in an in vivo mouse model of HBV replication. Results demonstrate that siRNA targeted to HBV and formulated as a stable nucleic-acid-lipid particle (SNALP) has high potency and activity in cell culture.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
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Know the enemy
Article Abstract:
The sequencing of 169 avian influenza virus (AIV) genomes provides a much-needed boost to preparations for a pandemic. The genetic data will facilitate understanding of the specific components of AIV that cause damage to the human body and provide basis for developing effective vaccines and therapies.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2006
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Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
Article Abstract:
A protamine-antibody fusion protein to deliver small interfering RNA to HIV-infected or envelope-transfected cells is designed. The potential for systemic, cell-type specific, antibody-mediated siRNA delivery is demonstrated.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
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