Small antibody mimetics comprising two complementarity-determining regions and a framework region for tumor targeting
Article Abstract:
The fusion of two complementarity-determining regions (CDRs), [V.sub.H]CDR1 and [V.sub.L]CDR3, through a cognate framework region ([V.sub.H]FR2) has produced mimetics that have retained the antigen recognition of their parent molecules, but have a superior capacity to penetrate tumors. The rational recombination of selected [V.sub.H]/[V.sub.L] binding sites and their framework regions have provided useful moieties for cytotoxic cancer therapies.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2007
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TAP expression provides a general method for improving the recognition of malignant cells in vivo
Article Abstract:
Transporters associated with antigen processing (TAP) are proteins that are essential in delivering antigenic peptides into the lumen of the endoplasmic reticulum. An experiment using the vaccinia virus containing the TAP gene demonstrated that it can reduce tumors and its inclusion in cancer therapies should be considered.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2000
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Pulsed electric fields for selection of hematopoietic cells and depletion of tumor cell contaminants
Article Abstract:
Researchers utilize a method in which hematopoietic cell selection is enhanced by exposing the cells to a pulsed electric field.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2000
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