Detection of the local structural changes in the dimer interface of BamHI initiated by DNA binding and dissociation using a solvatochromic fluorophore

Article Abstract:

A solvatochromic fluorescent [N.sup.[beta]]-L-alanyl-5-(N,N-dimethylamino)-napthalene-1-sulfonamide (DanAla) is introduced into 132 position of the dimer interface in BamHI to detect the local structural change in an interface between proteins induced by the substrate binding and dissociation. Detection of the changing structured is achieved which induced by substrate binding and dissociation using a steady-state and time-resolved fluoresence.

Proteins, Protein structure, DNA-ligand interactions, DNA binding, Substrates

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Single-molecule fluorescence imaging of the remote TiO(sub 2) photocatalytic oxidation

Article Abstract:

An investigation is performed on the remote TiO(sub 2) photocatalytic oxidation reaction of single dyes with the help of the single-molecule fluorescent imaging technique. The existence of unoxidized and oxidized dyes during the bleaching process of single dyes is indicated while analyzing the number, intensity and spectrum of individual fluorescence spots at the single-molecule level.

Titanium dioxide, Catalysis

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Hole transfer in DNA and photosensitized DNA damage: Importance of adenine oxidation

Article Abstract:

Photosensitized DNA damage reactions are investigated for two-known DNA-damaging photosensitizers (Sens), naphthalimide (NI) and napthaldimide (NDI), which have similar photophysical properties but different redox properties. The results have shown the importance of adenine (A)-oxidation, especially in consecutive A sequences, which triggers the rapid hole transfer between A's.

Biological Product (except Diagnostic) Manufacturing, Drugs, Adenine, DNA damage, Photosensitizing compounds, Photosensitizing agents, Report

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